Gudelsky G A, Koenig J I, Koyama T, Meltzer H Y
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Psychopharmacology (Berl). 1988;94(1):92-6. doi: 10.1007/BF00735887.
Maintenance of rats on a lithium-containing diet for 3-21 days resulted in a suppression of prolactin (PRL) secretion in vivo and in vitro. Lithium treatment also resulted in an increase in the activity of tuberoinfundibular dopaminergic neurons, as evidenced by an increased accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after inhibition of DOPA decarboxylase and an increased concentration of dopamine in the anterior pituitary gland. The accumulation of DOPA in the neurointermediate lobe of the pituitary gland, the prefrontal cortex, the striatum and the nucleus accumbens was also enhanced by lithium treatment. It is concluded that lithium treatment enhances the synthesis of dopamine in many brain regions and that an increased activity of tuberoinfundibular dopaminergic neurons results in an enhanced inhibitory control of PRL secretion.
给大鼠喂食含锂饮食3至21天，会导致体内和体外催乳素（PRL）分泌受到抑制。锂治疗还导致结节漏斗多巴胺能神经元的活性增加，这表现为在抑制多巴脱羧酶后，正中隆起中二羟基苯丙氨酸（DOPA）的积累增加，以及垂体前叶中多巴胺浓度升高。锂治疗还增强了垂体神经中间叶、前额叶皮质、纹状体和伏隔核中DOPA的积累。得出的结论是，锂治疗可增强许多脑区中多巴胺的合成，并且结节漏斗多巴胺能神经元活性的增加会导致对PRL分泌的抑制控制增强。
