Clark G D
Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, Missouri.
Clin Perinatol. 1989 Jun;16(2):459-74.
Glutamate, the major excitatory neurotransmitter of the brain, mediates neuronal injury from hypoxia-ischemia, hypoglycemia, and status epilepticus. Drugs that block glutamate receptors, particularly the N-methyl-D-aspartate (NMDA) receptor, protect neurons from these insults. Noncompetitive antagonists of NMDA receptors have the potential to prevent perinatal neurologic morbidity.
