从红蝉花茎中分离得到的新型抗菌孕甾糖苷。
New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea.
作者信息
Song Chang-Wei, Lunga Paul-Keilah, Qin Xu-Jie, Cheng Gui-Guang, Gu Jian-Long, Liu Ya-Ping, Luo Xiao-Dong
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Department of Biochemistry, Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, Yaoundé P.O. Box 812, Cameroon.
出版信息
Fitoterapia. 2014 Dec;99:267-75. doi: 10.1016/j.fitote.2014.10.008. Epub 2014 Oct 16.
Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A-H (1-8), together with one known pregnane glycoside ecdysantheroside A (9). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported literature data. Antimicrobial activities of all the compounds were evaluated against bacteria and yeasts. Compounds 1, 9, 3 and 5 exhibited moderate antibacterial activities against respective Enterococcus faecalis and Providensia smartii, with MIC value of 12.5 μg/mL. Compound 8 showed significant anti-yeast activity against Cryptococcus neoformans with MIC value of 12.5 μg/mL.
对红蝉花茎进行植物化学研究，从中分离出8个新的C-21孕甾烷糖苷蜕皮甾苷A-H（1-8），以及1个已知的孕甾烷糖苷红蝉花苷A（9）。通过广泛的光谱数据（质谱、红外光谱、一维和二维核磁共振）分析，并与已报道的文献数据进行比较，阐明了它们的结构。评估了所有化合物对细菌和酵母的抗菌活性。化合物1、9、3和5对粪肠球菌和史氏普罗威登斯菌分别表现出中等抗菌活性，最低抑菌浓度（MIC）值为12.5μg/mL。化合物8对新型隐球菌表现出显著的抗酵母活性，MIC值为12.5μg/mL。
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