Caronni Nicoletta, Savino Benedetta, Bonecchi Raffaella
Humanitas Clinical and Research Center, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
Humanitas Clinical and Research Center, Italy; Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Rozzano, Italy.
Immunobiology. 2015 Feb;220(2):249-53. doi: 10.1016/j.imbio.2014.10.001. Epub 2014 Oct 14.
Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines.
髓系细胞是癌症相关炎症的关键组成部分，不仅具有促进肿瘤生长的潜力，还能促进肿瘤侵袭和转移。肿瘤衍生因子影响髓系细胞分化，诱导出支持肿瘤生长、诱导免疫抑制、血管生成和组织重塑的表型。原发肿瘤部位产生的可溶性介质也能以远程方式发挥作用，诱导骨髓释放髓系细胞，这些髓系细胞在肿瘤引流淋巴器官中具有免疫抑制活性，迁移至转移器官时易引发肿瘤定植。我们将在此回顾目前关于肿瘤衍生信号对髓系细胞极化激活、骨髓释放及向转移部位募集的作用的相关知识，特别关注趋化因子的作用。
