Halbreich U, Assael M, Ben-David M
Psychopharmacology (Berl). 1978 Mar 1;56(2):167-71. doi: 10.1007/BF00431844.
Dibenzapine (720 mg, Noveril) was infused intravenously to 16 depressed patients during a period of 3 h. Serum prolactin levels were determined by radioimmunoassay and changes in clinical condition were evaluated according to the Hamilton Equation. The two variables were correlated to each other. In most of the patients Noveril caused a dramatic but short-lived improvement in depressive symptoms. There was much variability in the prolactin response to the drug. Serum prolactin levels showed a great elevation in 9 patients. In all patients the hormonal levels returned to their former normal levels after termination of the infusions. The treatment was then continued with Noveril per os. There was no significant correlation between serum prolactin levels and clinical condition or its change. The elevation of serum prolactin levels as a reaction to Noveril treatment may be explained by the prominent serotonergic action of Noveril. A time lag between serotonergic and dopaminergic actions of the drug when given in higher doses may be an additional explanation. Other possible hypotheses are discussed.
在3小时内，对16名抑郁症患者静脉输注二苯氮䓬（720毫克，诺韦尔）。通过放射免疫测定法测定血清催乳素水平，并根据汉密尔顿方程评估临床状况的变化。这两个变量相互关联。在大多数患者中，诺韦尔使抑郁症状有显著但短暂的改善。药物对催乳素的反应差异很大。9名患者的血清催乳素水平大幅升高。所有患者在输注结束后，激素水平恢复到先前的正常水平。然后继续口服诺韦尔进行治疗。血清催乳素水平与临床状况或其变化之间没有显著相关性。血清催乳素水平升高作为对诺韦尔治疗的反应，可能是由于诺韦尔突出的血清素能作用所致。当给予较高剂量时，药物的血清素能和多巴胺能作用之间的时间滞后可能是另一种解释。还讨论了其他可能的假设。
