Stevenazzi Andrea, Marchini Mattia, Sandrone Giovanni, Vergani Barbara, Lattanzio Maria
Italfarmaco Research Centre, Italfarmaco SpA, Via dei Lavoratori 54, I-20092 Cinisello Balsamo, Milan, Italy.
Bioorg Med Chem Lett. 2014 Dec 1;24(23):5349-56. doi: 10.1016/j.bmcl.2014.10.016. Epub 2014 Oct 13.
The unnatural amino acids (UAAs) are members of a class of molecules with relevant impacts in the life sciences. Due to the role of these molecules in the modulation of the chemical and physical properties of biological and inorganic materials, UAAs have attracted increasing interest in recent years. The aim of this review is to highlight (i) the most recent and innovative synthetic routes for the preparation of UAAs, (ii) the recently marketed UAA-based drugs, and (iii) the most promising technological applications involving novel UAA-containing molecular entities.
非天然氨基酸（UAAs）是一类在生命科学中具有相关影响的分子成员。由于这些分子在调节生物和无机材料的化学和物理性质方面的作用，近年来非天然氨基酸已引起越来越多的关注。本综述的目的是强调：（i）制备非天然氨基酸的最新和创新合成路线；（ii）最近上市的基于非天然氨基酸的药物；以及（iii）涉及新型含非天然氨基酸分子实体的最有前景的技术应用。
