Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes.
作者信息
Zhang Yan, Shen Mingyun, Cui Sunliang, Hou Tingjun
机构信息
Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Institute of Materia Medica and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
出版信息
Bioorg Med Chem Lett. 2014 Dec 1;24(23):5470-2. doi: 10.1016/j.bmcl.2014.10.009. Epub 2014 Oct 13.
A simple synthesis of 2-hydroxylated (E)-stilbenes was accomplished in good yields via oxidative coupling of 2-hydroxystyrenes and arylboronic acids, with Rh(III)-catalyst and Cu(OAc)2 as oxidant. The antiproliferative evaluation of all the synthesized compounds were assessed on four different human cancer cell lines (Colo-205, MDA-468, HT29, and MGC80-3), and the results showed that several compounds exhibit strong antiproliferative activities (up to IC50=35 nM for MGC80-3).
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