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中国人群中新婚夫妇的不孕发生率及生育力受损的危险因素。

Incidence of infertility and risk factors of impaired fecundity among newly married couples in a Chinese population.

作者信息

Meng Qinqin, Ren Aiguo, Zhang Le, Liu Jufen, Li Zhiwen, Yang Yan, Li Rong, Ma Le

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 College Rd, Haidian District, Beijing, China; Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University Health Science Center, 38 College Rd, Haidian District, Beijing, China.

Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University Health Science Center, 38 College Rd, Haidian District, Beijing, China.

出版信息

Reprod Biomed Online. 2015 Jan;30(1):92-100. doi: 10.1016/j.rbmo.2014.10.002. Epub 2014 Oct 13.

Abstract

The aims of this study were to obtain the incidence of infertility, to examine the causes of infertility and to explore risk factors for impaired fecundity in a rural region of northern China using a prospective follow-up design. A total of 2151 newly married couples planning to become pregnant within the next 12 months were enrolled between 2009 and 2012 from two counties of Shanxi Province in northern China. Couples were followed up for at least 1 year or until a clinical pregnancy occurred. Information about clinical pregnancy was obtained. The 12-month and 24-month infertility rates were 13.6% (95% CI 11.9 to 15.3) and 8.5% (95% CI 6.7 to 10.3), respectively. About 63% of women became pregnant within 6 months of follow up, and 86% did so within 12 months of follow up. The main causes of female infertility were ovulation disorders, fallopian tube problems and polycystic ovary syndrome. The primary cause of male infertility was sperm quality problems. Couples who used coal as cooking fuel, women with a higher body mass index, women with long-term health problems, and men who had married at later ages were more likely to have delayed pregnancies.

摘要

本研究旨在采用前瞻性随访设计,获取中国北方某农村地区的不孕发生率,研究不孕原因,并探索生育力受损的风险因素。2009年至2012年期间,从中国北方山西省的两个县招募了总共2151对计划在未来12个月内怀孕的新婚夫妇。对夫妇进行至少1年的随访,或直至临床妊娠发生。获取有关临床妊娠的信息。12个月和24个月的不孕率分别为13.6%(95%CI 11.9至15.3)和8.5%(95%CI 6.7至10.3)。约63%的女性在随访6个月内怀孕,86%的女性在随访12个月内怀孕。女性不孕的主要原因是排卵障碍、输卵管问题和多囊卵巢综合征。男性不孕的主要原因是精子质量问题。以煤为烹饪燃料的夫妇、体重指数较高的女性、有长期健康问题的女性以及晚婚男性更有可能出现怀孕延迟。

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