Sallée Camille, Margueritte François, Marquet Pierre, Piver Pascal, Aubard Yves, Lavoué Vincent, Dion Ludivine, Gauthier Tristan
Department of Gynecology and Obstetrics, Mother and Child Hospital, University Hospital Center of Limoges, 87000 Limoges, France.
Department of Gynecology and Obstetrics, Intercommunal Hospital Center of Poissy-Saint-Germain-en-Laye, 78103 Poissy, France.
J Clin Med. 2022 Aug 21;11(16):4907. doi: 10.3390/jcm11164907.
Uterine factor infertility (UFI) is defined as a condition resulting from either a complete lack of a uterus or a non-functioning uterus due to many causes. The exact prevalence of UFI is currently unknown, while treatments to achieve pregnancy are very limited. To evaluate the prevalence of this condition within its different causes, we carried out a worldwide systematic review on UFI. We performed research on the prevalence of UFI and its various causes throughout the world, according to the PRISMA criteria. A total of 188 studies were included in qualitative synthesis. UFI accounted for 2.1 to 16.7% of the causes of female infertility. We tried to evaluate the proportion of the different causes of UFI: uterine agenesia, hysterectomies, uterine malformations, uterine irradiation, adenomyosis, synechiae and Asherman syndrome, uterine myomas and uterine polyps. However, the data available in countries and studies were highly heterogenous. This present systematic review underlines the lack of a consensual definition of UFI. A national register of patients with UFI based on a consensual definition of Absolute Uterine Factor Infertility and Non-Absolute Uterine Factor Infertility would be helpful for women, whose desire for pregnancy has reached a dead end.
子宫因素不孕症（UFI）被定义为一种因完全没有子宫或因多种原因导致子宫无法正常运作而引发的病症。目前尚不清楚UFI的确切患病率，而实现妊娠的治疗方法非常有限。为了评估这种病症在不同病因中的患病率，我们对UFI进行了一项全球系统性综述。我们根据PRISMA标准，对世界各地UFI的患病率及其各种病因进行了研究。共有188项研究纳入了定性综合分析。UFI占女性不孕病因的2.1%至16.7%。我们试图评估UFI不同病因的占比：子宫发育不全、子宫切除术、子宫畸形、子宫放疗、子宫腺肌病、粘连和阿谢曼综合征、子宫肌瘤和子宫息肉。然而，各国及各项研究中可得的数据具有高度异质性。本系统性综述强调了UFI缺乏共识性定义这一情况。基于绝对子宫因素不孕症和非绝对子宫因素不孕症的共识性定义建立UFI患者国家登记册，将对那些妊娠愿望陷入绝境的女性有所帮助。
