Aaron Carrie P, Schwartz Joseph E, Bielinski Suzette J, Hoffman Eric A, Austin John H M, Oelsner Elizabeth C, Donohue Kathleen M, Kalhan Ravi, Berardi Cecilia, Kaufman Joel D, Jacobs David R, Tracy Russell P, Barr R Graham
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Respir Med. 2015 Feb;109(2):255-64. doi: 10.1016/j.rmed.2014.10.004. Epub 2014 Oct 22.
Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline.
The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors.
Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function.
Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.
内皮细胞间黏附分子（ICAM）-1可结合中性粒细胞并促进其迁移至肺内；E-选择素则促进白细胞滚动。由于中性粒细胞在肺气肿和慢性阻塞性肺疾病中会导致组织破坏，我们推测可溶性ICAM-1（sICAM-1）和E-选择素（sE-选择素）与肺气肿的纵向进展及肺功能下降有关。
动脉粥样硬化多民族研究（MESA）于2000 - 2002年招募了45 - 84岁无临床心血管疾病的参与者。MESA肺部研究评估了心脏CT扫描（2000 - 2007年）和全肺CT扫描（2010 - 2012年）上的肺气肿百分比（<-950亨氏单位），并在五年内对肺功能进行了两次肺活量测定。在基线时测量sICAM-1和sE-选择素。混合效应模型对人口统计学、人体测量学、吸烟、C反应蛋白、鞘磷脂和扫描因素进行了校正。
在1865名进行了sICAM-1和肺气肿百分比测量的MESA肺部参与者中，sICAM-1的平均对数为5.5±0.3 ng/mL，肺气肿百分比在十年内增加了0.73个百分点（95%CI：0.34，1.12；P<0.001）。sICAM-1每增加一个标准差，与十年内肺气肿百分比加速增加0.23个百分点相关（95%CI：0.06，0.39；P = 0.007）。未发现sE-选择素存在显著关联，也未发现任何黏附分子与肺功能之间存在显著关联。
在一般人群样本中，较高水平的sICAM-1与肺气肿百分比的进展独立相关。
