突变果蝇睾丸干细胞“性别转换”，告别雄性。
chinmo Mutant fly testis stem cells switching sex farewell to maleness.
机构信息
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Dev Cell. 2014 Nov 24;31(4):385-7. doi: 10.1016/j.devcel.2014.11.001.
PMID:25458005
Abstract
Maintaining cellular identity is crucial for homeostasis, and sexual fates of vertebrate testis and ovary cells require continual reinforcement. In this issue of Developmental Cell, Ma et al. (2014) provide insights into stem cell fate maintenance in Drosophila, finding that the JAK/STAT target chinmo prevents transformation of testis somatic stem cells into their ovarian counterparts.
摘要
维持细胞的身份对于体内平衡至关重要，脊椎动物睾丸和卵巢细胞的性命运需要持续加强。在本期《发育细胞》中，马等人（2014）提供了关于果蝇干细胞命运维持的见解，发现 JAK/STAT 靶标 chinmo 可防止睾丸体干细胞转化为卵巢对应物。
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