果蝇中JAK/STAT信号通路对干细胞的调控
Stem cell regulation by JAK/STAT signaling in Drosophila.
作者信息
Gregory Lorna, Came Paul J, Brown Stephen
机构信息
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
出版信息
Semin Cell Dev Biol. 2008 Aug;19(4):407-13. doi: 10.1016/j.semcdb.2008.06.003. Epub 2008 Jun 18.
Stem cells have become one of the "buzz" topics in the last decade or so. One of the best systems to study adult stem cells in vivo is in the model organism, Drosophila melanogaster. One hundred years of genetic analysis, a sequenced and highly annotated genome and genomics makes this a difficult organism to avoid. The JAK/STAT pathway has been shown to regulate stem cells during haematopoiesis and gametogenesis in Drosophila. In this review we cover the current literature and contrast each group of stem cells with respect to JAK/STAT signaling.
在过去十年左右的时间里，干细胞已成为热门话题之一。研究成年干细胞体内情况的最佳系统之一是模式生物黑腹果蝇。经过一百年的遗传分析、一个已测序且注释丰富的基因组以及基因组学研究，使得很难避开这种生物。JAK/STAT信号通路已被证明在果蝇的造血和配子发生过程中调节干细胞。在这篇综述中，我们涵盖了当前的文献，并就JAK/STAT信号传导对每组干细胞进行了对比。
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