Uzun Sennur, Erden Ismail A, Canbay Ozgur, Aypar Ulku
Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.
Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.
Kaohsiung J Med Sci. 2014 Nov;30(11):566-9. doi: 10.1016/j.kjms.2014.08.002. Epub 2014 Sep 22.
Rocuronium is a nondepolarizing neuromuscular blocking agent used in anesthesia induction and is associated with considerable discomfort and burning pain during injection, which is reported to occur in 50-80% of patients. This study was carried out to investigate the effectiveness of intravenous paracetamol pretreatment compared with lidocaine and normal saline to prevent rocuronium injection pain. The study included 150 ASA I-II patients undergoing elective orthopedic, gastrointestinal, and gynecological procedures under general anesthesia. They were allocated into three groups according to pretreatment drugs: lidocaine (40 mg) (n = 50), paracetamol (n = 50), and normal saline group (n = 50). Before anesthesia induction with propofol, all patients were pretreated with rocuronium. The pain caused by the injection was evaluated. Local signs were assessed on the arm at the end of the injection, as well as 24 hours after recovery from anesthesia. There were no patients with blurred speech or vision and there was no respiratory depression in any group after pretreatment with the study drug. The level of pain on injection was statistically lower in those who had received paracetamol compared to normal saline (p = 0.009). There were more patients in the saline group with severe pain (p < 0.001). Paracetamol relieved the rocuronium injection pain better than normal saline but lidocaine was the best of the three drugs (p < 0.001).
罗库溴铵是一种用于麻醉诱导的非去极化神经肌肉阻滞剂，注射时会引起相当程度的不适和灼痛，据报道50%-80%的患者会出现这种情况。本研究旨在调查静脉注射对乙酰氨基酚预处理与利多卡因和生理盐水相比预防罗库溴铵注射痛的有效性。该研究纳入了150例接受全身麻醉下择期骨科、胃肠道和妇科手术的ASA I-II级患者。根据预处理药物将他们分为三组：利多卡因（40mg）（n=50）、对乙酰氨基酚（n=50）和生理盐水组（n=50）。在用丙泊酚进行麻醉诱导前，所有患者均预先注射罗库溴铵。评估注射引起的疼痛。在注射结束时以及麻醉恢复后24小时评估手臂的局部体征。预处理研究药物后，没有患者出现言语或视力模糊，任何组均未出现呼吸抑制。与生理盐水组相比，接受对乙酰氨基酚的患者注射时的疼痛程度在统计学上更低（p=0.009）。生理盐水组有更多患者出现严重疼痛（p<0.001）。对乙酰氨基酚比对生理盐水更能缓解罗库溴铵注射痛，但利多卡因是三种药物中效果最好的（p<0.001）。
