Rosales Nieto C A, Thompson A N, Macleay C A, Briegel J R, Hedger M P, Ferguson M B, Martin G B
CRC for Sheep Industry Innovation and the University of New England, Armidale, NSW 2351, Australia; Department of Agriculture and Food of Western Australia, South Perth, WA 6151, Australia; The UWA Institute of Agriculture and School of Animal Biology, University of Western Australia, Crawley, WA 6009, Australia.
CRC for Sheep Industry Innovation and the University of New England, Armidale, NSW 2351, Australia; Department of Agriculture and Food of Western Australia, South Perth, WA 6151, Australia; School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia.
Anim Reprod Sci. 2014 Dec 30;151(3-4):148-56. doi: 10.1016/j.anireprosci.2014.10.008. Epub 2014 Oct 16.
The onset of puberty depends on the attainment of critical body mass, so should also be affected by increases in the rate of accumulation of muscle and adipose tissue. Adipose tissue and reproduction are linked by leptin. For muscle, a link has not yet been identified, although one possibility is follistatin. We assessed the relationships among circulating concentrations of follistatin and leptin and the rates of growth and accumulation of muscle and fat during pubertal development in female sheep. We used 326 animals with known phenotypic values for live weight (LW), depths of eye muscle (EMD) and fat (FAT), and known breeding values at post-weaning age for body mass (PWT) and depths of eye muscle (PEMD) and fat (PFAT). Leptin concentration was positively correlated with values for EMD, PEMD, FAT, PFAT, LW and PWT (P<0.001), whereas follistatin concentration was negatively correlated with values for EMD and PWT (P<0.001), and PEMD (P<0.01) and FAT (P<0.05). Leptin concentration was negatively related to age and positively related to live weight at first oestrus and the proportion of females that attained puberty (P≤0.05), and to fertility and reproductive rate (P<0.01). Follistatin concentration was negatively related to live weight at first oestrus and to fertility (P<0.01) and reproductive rate (P<0.05). There were positive correlations (P<0.001) between muscle accumulation and leptin concentration, and between muscle accumulation and reproductive performance. We conclude that leptin and follistatin are probably both involved in effects of accelerated accumulation of muscle and adipose tissues on the onset of puberty.
青春期的开始取决于关键体重的达成，因此也应受到肌肉和脂肪组织积累速率增加的影响。脂肪组织与生殖通过瘦素相联系。对于肌肉而言，尽管一种可能性是卵泡抑素，但尚未确定其联系。我们评估了卵泡抑素和瘦素的循环浓度与雌性绵羊青春期发育期间肌肉和脂肪的生长及积累速率之间的关系。我们使用了326只动物，它们具有已知的体重（LW）、眼肌深度（EMD）和脂肪（FAT）的表型值，以及断奶后年龄时的体重（PWT）、眼肌深度（PEMD）和脂肪（PFAT）的已知育种值。瘦素浓度与EMD、PEMD、FAT、PFAT、LW和PWT的值呈正相关（P<0.001），而卵泡抑素浓度与EMD和PWT的值呈负相关（P<0.001），与PEMD（P<0.01）和FAT（P<0.05）呈负相关。瘦素浓度与年龄呈负相关，与初情期时的体重、达到青春期的雌性比例呈正相关（P≤0.05），与生育力和繁殖率呈正相关（P<0.01）。卵泡抑素浓度与初情期时的体重、生育力（P<0.01）和繁殖率（P<0.05）呈负相关。肌肉积累与瘦素浓度之间以及肌肉积累与生殖性能之间存在正相关（P<0.001）。我们得出结论，瘦素和卵泡抑素可能都参与了肌肉和脂肪组织加速积累对青春期开始的影响。
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