Martin M V
Department of Dental Surgery, Dental School, University of Liverpool, U.K.
J Med Vet Mycol. 1989;27(2):63-70. doi: 10.1080/02681218980000101.
The efficacy of fluconazole and ketoconazole in the treatment of rat palatal candidosis has been investigated. To induce oral candidosis, the palatal tissues of Wistar rats were inoculated with Candida albicans NCPF 3091 and covered with acrylic plates. The rats were treated with either fluconazole or ketoconazole by intragastric gavage for 14 days. Palatal epithelial thickness, the number of yeasts present and the histopathological appearance of the tissue were assessed to compare treatment with the two azoles. A fluconazole dose of 0.75 mg kg-1 body weight once daily for 14 days was required to cure the palatal candidosis and prevent recrudescence, whereas with ketoconazole a dose of 7.0 mg kg-1 body weight was necessary to achieve the same effect. From these results it is concluded that fluconazole is effective at a dose nine times lower than ketoconazole in resolving rat palatal candidosis.
已对氟康唑和酮康唑治疗大鼠腭部念珠菌病的疗效进行了研究。为诱导口腔念珠菌病，将白色念珠菌NCPF 3091接种到Wistar大鼠的腭部组织上，并用丙烯酸板覆盖。通过灌胃法给大鼠使用氟康唑或酮康唑治疗14天。评估腭部上皮厚度、存在的酵母菌数量和组织的组织病理学外观，以比较两种唑类药物的治疗效果。治愈腭部念珠菌病并防止复发需要每天一次给予0.75 mg kg-1体重的氟康唑，持续14天，而对于酮康唑，则需要7.0 mg kg-1体重的剂量才能达到相同效果。从这些结果可以得出结论，在解决大鼠腭部念珠菌病方面，氟康唑的有效剂量比酮康唑低九倍。
