van der Wal N, Baak J P, Schipper N W, van der Waal I
Department of Oral Pathology, ACTA/Free University, Amsterdam, The Netherlands.
J Oral Pathol Med. 1989 Jan;18(1):8-10. doi: 10.1111/j.1600-0714.1989.tb00723.x.
Several reports have mentioned the possibility of misdiagnosing pseudoepitheliomatous hyperplasia (PEH) of the overlying mucosa of a granular cell tumor as a squamous cell carcinoma (SCC). Because of this, morphometry was applied to five granular cell tumors with PEH and five well-differentiated SCC of the tongue. In addition, ten normal tongues have been examined. The mean area, the mean perimeter and the mean diameter of the 50 largest squamous epithelial nuclei in 50 fields were found to be significantly larger in squamous cell carcinomas than in granular cell tumors and normal tongues. The shape factor of the nucleus and the mitotic activity appeared to be of no significant value in this respect.
几份报告提到了将颗粒细胞瘤上覆黏膜的假上皮瘤样增生（PEH）误诊为鳞状细胞癌（SCC）的可能性。因此，对5例伴有PEH的颗粒细胞瘤和5例舌部高分化SCC进行了形态测量。此外，还检查了10个正常舌组织。发现50个视野中50个最大鳞状上皮细胞核的平均面积、平均周长和平均直径在鳞状细胞癌中显著大于颗粒细胞瘤和正常舌组织。在这方面，细胞核的形状因子和有丝分裂活性似乎没有显著价值。
