Daniels John Spencer M
Department of Oral and Maxillofacial Surgery, Regional Dental Centre, King Khalid Hospital, P.O. Box 1120, Najran, Saudi Arabia.
Saudi Dent J. 2009 Jul;21(2):75-8. doi: 10.1016/j.sdentj.2009.07.004.
Granular cell tumour, also known as Abrikossoff tumour, is a relatively uncommon benign neoplasm, which is more commonly found in females in the 4th to 6th decades of life even though it can occur in all ages. It occurs in all areas of the body but about 45-65% of all lesions are reported in the head and neck region. Intraoral lesions represent about 70% of the granular cell tumours of the head and neck, and account for 1/3 of all cases affecting the whole body. Most of the intraoral lesions occur on the tongue, usually on the lateral aspect, followed by the buccal mucosa and hard palate. Although majority of granular cell tumours are benign, some are clinically aggressive and a few frankly malignant forms have been reported. Some benign lesions exhibit surface ulcerations and this clinical appearance, combined with the overlying pseudoepitheliomatous hyperplasia, seen histologically, may lead to misdiagnosis of malignancy if adequate biopsy material was not taken. A case of granular cell tumour which occurred on the midline area of the dorsum of the posterior 1/3 of the tongue is reported in a 20-year-old female patient. It is interesting because the patient was younger than the average age of occurrence and the tumour occurred in a similar site to that of a lingual thyroid.
颗粒细胞瘤,也称为阿布里科索夫瘤,是一种相对罕见的良性肿瘤,尽管可发生于所有年龄段,但更常见于40至60岁的女性。它可发生于身体的各个部位,但据报道,所有病变中约45%至65%发生在头颈部区域。口腔内病变约占头颈部颗粒细胞瘤的70%,占全身所有病例的1/3。大多数口腔内病变发生在舌部,通常在舌外侧,其次是颊黏膜和硬腭。虽然大多数颗粒细胞瘤是良性的,但有些具有临床侵袭性,并且有少数报道为明显的恶性形式。一些良性病变表现为表面溃疡,这种临床表现,加上组织学上所见的上皮假瘤样增生,如果没有获取足够的活检材料,可能会导致恶性肿瘤的误诊。本文报道了一例发生于一名20岁女性患者舌背中后1/3中线区域的颗粒细胞瘤。该病例很有趣,因为患者年龄低于发病平均年龄,且肿瘤发生部位与舌甲状腺相似。