Panitch Howard B
Professor of Pediatrics, Perelman School of Medicine at The University of Pennsylvania, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia.
Paediatr Respir Rev. 2015 Jan;16(1):11-7. doi: 10.1016/j.prrv.2014.10.004. Epub 2014 Oct 23.
The abdominal wall is an integral component of the chest wall. Defects in the ventral abdominal wall alter respiratory mechanics and can impair diaphragm function. Congenital abdominal wall defects also are associated with abnormalities in lung growth and development that lead to pulmonary hypoplasia, pulmonary hypertension, and alterations in thoracic cage formation. Although infants with ventral abdominal wall defects can experience life-threatening pulmonary complications, older children typically experience a more benign respiratory course. Studies of lung and chest wall function in older children and adolescents with congenital abdominal wall defects are few; such investigations could provide strategies for improved respiratory performance, avoidance of respiratory morbidity, and enhanced exercise ability for these children.
腹壁是胸壁的一个组成部分。腹前壁缺损会改变呼吸力学，并可能损害膈肌功能。先天性腹壁缺损还与肺生长发育异常有关，可导致肺发育不全、肺动脉高压和胸廓形成改变。虽然腹前壁缺损的婴儿可能会出现危及生命的肺部并发症，但大龄儿童通常呼吸过程较为良性。针对先天性腹壁缺损的大龄儿童和青少年的肺与胸壁功能的研究较少；此类研究可为改善这些儿童的呼吸功能、避免呼吸疾病以及增强运动能力提供策略。
