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先天性膈疝：证据何在及存在于何处？

Congenital diaphragmatic hernia: where and what is the evidence?

作者信息

Losty Paul D

机构信息

Department of Paediatric Surgery, Alder Hey Children׳s Hospital NHS Foundation Trust, University of Liverpool, Liverpool, UK.

出版信息

Semin Pediatr Surg. 2014 Oct;23(5):278-82. doi: 10.1053/j.sempedsurg.2014.09.008. Epub 2014 Sep 4.

DOI:10.1053/j.sempedsurg.2014.09.008
PMID:25459012
Abstract

Congenital diaphragmatic hernia (CDH) retains high mortality and morbidity due to lung hypoplasia, pulmonary hypertension and severe co-existent anomalies. This article offers a comprehensive state-of-the-art review for the paediatric surgeon whilst also describing key contributions from the basic sciences in the search to uncover the cause of the birth defect together with efforts to develop new and better therapies for CDH.

摘要

先天性膈疝（CDH）由于肺发育不全、肺动脉高压以及严重的并存畸形，死亡率和发病率居高不下。本文为小儿外科医生提供了一份全面的最新综述，同时还描述了基础科学在探寻该出生缺陷病因方面的关键贡献，以及为先天性膈疝开发更新、更好治疗方法所做的努力。

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