现代产科学中的早产预防
Prevention of preterm birth in modern obstetrics.
作者信息
Markham Kara B, Klebanoff Mark
机构信息
Maternal Fetal Medicine Division, Department of Obstetrics & Gynecology, The Ohio State University College of Medicine, 395 West 12th Avenue, 5th Floor, Columbus, OH 43210, USA.
Department of Pediatrics, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Obstetrics and Gynecology, The Ohio State University, 395 West 12th Avenue, 5th Floor, Columbus, OH 43210, USA; Division of Epidemiology, The Ohio State University College of Public Health, 250 Cunz Hall, 1841 Neil Avenue, Columbus, OH 43210, USA; Center for Perinatal Research, The Research Institute, Nationwide Children's Hospital, 700 Children's Drive, WB 5231, Columbus, OH 43205, USA.
出版信息
Clin Perinatol. 2014 Dec;41(4):773-85. doi: 10.1016/j.clp.2014.08.003. Epub 2014 Sep 26.
Spontaneous preterm labor is a complex process characterized by the interplay of multiple different pathways. Prevention of preterm labor and delivery is also complicated. The most effective interventions for prevention of preterm birth (PTB) are progestin prophylaxis and lifestyle modifications, with cerclage placement also playing a role in selected populations. Interventions such as activity modification, home tocometry, and routine antibiotic use have fallen out of favor because of lack of effectiveness and possibility of harm. The solution to the problem of PTB remains elusive, and researchers and clinicians must collaborate to find a cure for preterm labor.
自发性早产是一个复杂的过程，其特征是多种不同途径相互作用。预防早产和分娩也很复杂。预防早产最有效的干预措施是孕激素预防和生活方式改变，宫颈环扎术在特定人群中也发挥作用。诸如改变活动方式、家庭宫缩监测和常规使用抗生素等干预措施，由于缺乏有效性和可能造成伤害，已不再受到青睐。早产问题的解决方案仍然难以捉摸，研究人员和临床医生必须合作寻找治疗早产的方法。
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