益生菌与坏死性小肠结肠炎
Probiotics and necrotizing enterocolitis.
作者信息
Neu Josef
机构信息
University of Florida, Department of Pediatrics, Division of Neonatology, 1600 Southwest Archer Road, Human Development Building, HD 112, Gainesville, FL 32610, USA.
出版信息
Clin Perinatol. 2014 Dec;41(4):967-78. doi: 10.1016/j.clp.2014.08.014. Epub 2014 Sep 30.
Abstract
One of the most controversial areas in neonatology is whether probiotics should be provided routinely to preterm infants to prevent necrotizing enterocolitis (NEC). This review provides the reader with a brief overview of NEC and current concepts of its pathophysiology, discusses the microbial ecology of the intestine in preterm infants and factors that may lead to a "dysbiosis", summarizes studies of probiotics in preterm infants, elaborates on the need for regulation in this area, and discusses alternatives to probiotics and what is the future for the prevention of NEC.
摘要
新生儿学中最具争议的领域之一是是否应常规给早产儿提供益生菌以预防坏死性小肠结肠炎（NEC）。本综述为读者简要概述了NEC及其病理生理学的当前概念，讨论了早产儿肠道的微生物生态学以及可能导致“生态失调”的因素，总结了早产儿益生菌的研究，阐述了该领域监管的必要性，并讨论了益生菌的替代方法以及预防NEC的未来发展方向。
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