受体相互作用蛋白激酶-1的两面性
The two faces of receptor interacting protein kinase-1.
作者信息
Weinlich Ricardo, Green Douglas R
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
出版信息
Mol Cell. 2014 Nov 20;56(4):469-80. doi: 10.1016/j.molcel.2014.11.001.
Abstract
Receptor Interacting Protein Kinase-1 (RIPK1), a key player in inflammation and cell death, assumes opposite functions depending on the cellular context and its posttranslational modifications. Genetic evidence supported by biochemical and cellular biology approaches sheds light on the circumstances in which RIPK1 promotes or inhibits these processes.
摘要
受体相互作用蛋白激酶-1（RIPK1）是炎症和细胞死亡中的关键因子，其功能取决于细胞环境及其翻译后修饰。生物化学和细胞生物学方法支持的遗传学证据揭示了RIPK1促进或抑制这些过程的情况。
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