受体相互作用蛋白激酶-1的两面性
The two faces of receptor interacting protein kinase-1.
作者信息
Weinlich Ricardo, Green Douglas R
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
出版信息
Mol Cell. 2014 Nov 20;56(4):469-80. doi: 10.1016/j.molcel.2014.11.001.
Abstract
Receptor Interacting Protein Kinase-1 (RIPK1), a key player in inflammation and cell death, assumes opposite functions depending on the cellular context and its posttranslational modifications. Genetic evidence supported by biochemical and cellular biology approaches sheds light on the circumstances in which RIPK1 promotes or inhibits these processes.
摘要
受体相互作用蛋白激酶-1（RIPK1）是炎症和细胞死亡中的关键因子，其功能取决于细胞环境及其翻译后修饰。生物化学和细胞生物学方法支持的遗传学证据揭示了RIPK1促进或抑制这些过程的情况。
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本文引用的文献
1
RIP3 induces apoptosis independent of pronecrotic kinase activity.RIP3诱导细胞凋亡，与坏死前激酶活性无关。
Mol Cell. 2014 Nov 20;56(4):481-95. doi: 10.1016/j.molcel.2014.10.021.
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RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.RNA 病毒通过 RIP1-RIP3-DRP1 信号通路促进 NLRP3 炎性小体的激活。
Nat Immunol. 2014 Dec;15(12):1126-33. doi: 10.1038/ni.3015. Epub 2014 Oct 19.
3
RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis.RIPK1 可以作为 RIPK3 依赖性细胞坏死的抑制剂，而不是起始因子。
FEBS J. 2014 Nov;281(21):4921-34. doi: 10.1111/febs.13034. Epub 2014 Oct 4.
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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.RIPK1 通过保护上皮细胞免受细胞凋亡来确保肠道内环境稳定。
Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706.
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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.RIPK1 通过抑制细胞凋亡和坏死性凋亡来维持上皮细胞的稳态。
Nature. 2014 Sep 4;513(7516):90-4. doi: 10.1038/nature13608. Epub 2014 Aug 17.
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Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.前沿：RIPK1 激酶失活小鼠具有活力，并可防止体内 TNF 诱导的坏死性凋亡。
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