Layton Thomas Benjamin
University of Manchester, United Kingdom.
Int J Surg Case Rep. 2014;5(12):1072-3. doi: 10.1016/j.ijscr.2014.10.072. Epub 2014 Nov 4.
To illustrate the potential side effects and clinical efficacy of Botox injections in treating sialorrhoea.
A 26-year-old patient with cerebral palsy with dystonia had a long history of severe, distressing sialorrhoea. She was treated with three separate Botox injections into her salivary glands in December 2011, July 2012 and March 2013.
Following the Botox injections the patient developed dysphagia, began to expectorate thick mucus and developed a cough; she was treated for a chest injection and during this time her feeding deteriorated. Three injections were given as the patient had an objective and significant reduction in salivation. However, the side effect profile was deemed too great to continue with treatment.
Botox is a novel and effective treatment for reducing saliva production. Its clinical efficacy is supported by this case and correlates with the recent literature. Although rare, significant side effects can happen and the case presented illustrates the care needed when administering injections, particularly in a subgroup of patients.
阐述肉毒杆菌毒素注射治疗流涎症的潜在副作用及临床疗效。
一名26岁患有肌张力障碍的脑瘫患者，有严重且令人苦恼的流涎症病史已久。她于2011年12月、2012年7月和2013年3月分别接受了三次肉毒杆菌毒素注射到唾液腺。
肉毒杆菌毒素注射后，患者出现吞咽困难，开始咳出浓稠黏液并出现咳嗽；她因胸部感染接受治疗，在此期间其进食情况变差。因患者流涎客观且显著减少，所以进行了三次注射。然而，副作用被认为太大，无法继续治疗。
肉毒杆菌毒素是一种减少唾液分泌的新型有效治疗方法。该病例支持其临床疗效，且与近期文献相符。虽然罕见，但可能发生严重副作用，本病例表明注射时需要谨慎，尤其是在特定患者亚组中。
