Hegedűs Csaba, Virág László
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., H-4032 Debrecen, Hungary.
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., H-4032 Debrecen, Hungary; MTA-DE Cell Biology and Signaling Research Group, Debrecen, Hungary.
Redox Biol. 2014;2:978-82. doi: 10.1016/j.redox.2014.08.003. Epub 2014 Aug 21.
Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARP-1 and review the cellular functions regulated by the enzyme.
氧化应激可导致DNA断裂，进而诱导DNA切口传感器酶聚（ADP - 核糖）聚合酶 - 1（PARP - 1）激活，PARP - 1是由17个成员组成的PARP酶家族的一部分。PARP - 1通过将几个源自NAD的ADP - 核糖单元附着到靶蛋白上形成聚（ADP - 核糖）（PAR）聚合物，从而修饰靶蛋白。PAR化控制许多细胞过程，而强烈的PAR化也可能通过各种机制导致细胞死亡。在此，我们总结PARP - 1的激活模式、抑制剂和调节剂，并综述该酶调节的细胞功能。
