Translational Medical Innovation Center, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, China.
Department of Anesthesiology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, China.
Cell Biol Toxicol. 2024 Aug 2;40(1):63. doi: 10.1007/s10565-024-09895-0.
Anesthetic-induced developmental neurotoxicity (AIDN) can arise due to various factors, among which aberrant nerve cell death is a prominent risk factor. Animal studies have reported that repeated or prolonged anesthetic exposure can cause significant neuroapoptosis in the developing brain. Lately, non-apoptotic programmed cell deaths (PCDs), characterized by inflammation and oxidative stress, have gained increasing attention. Substantial evidence suggests that non-apoptotic PCDs are essential for neuronal cell death in AIDN compared to apoptosis. This article examines relevant publications in the PubMed database until April 2024. Only original articles in English that investigated the potential manifestations of non-apoptotic PCD in AIDN were analysed. Specifically, it investigates necroptosis, pyroptosis, ferroptosis, and parthanatos, elucidating the signaling mechanisms associated with each form. Furthermore, this study explores the potential relevance of these non-apoptotic PCDs pathways to the pathological mechanisms underlying AIDN, drawing upon their distinctive characteristics. Despite the considerable challenges involved in translating fundamental scientific knowledge into clinical therapeutic interventions, this comprehensive review offers a theoretical foundation for developing innovative preventive and treatment strategies targeting non-apoptotic PCDs in the context of AIDN.
麻醉诱导的发育性神经毒性（AIDN）可能由多种因素引起，其中异常的神经细胞死亡是一个突出的风险因素。动物研究报告称，反复或长时间暴露于麻醉剂会导致发育中的大脑发生显著的神经细胞凋亡。最近，非凋亡程序性细胞死亡（PCD），其特征为炎症和氧化应激，引起了越来越多的关注。大量证据表明，与凋亡相比，非凋亡 PCD 对于 AIDN 中的神经元细胞死亡是必不可少的。本文对截至 2024 年 4 月的 PubMed 数据库中的相关出版物进行了审查。仅分析了以英语发表的、研究 AIDN 中非凋亡 PCD 潜在表现的原创文章。具体而言，本文研究了坏死性凋亡、细胞焦亡、铁死亡和 Parthanatos，阐明了与每种形式相关的信号机制。此外，本研究还探讨了这些非凋亡 PCD 途径与 AIDN 病理机制的潜在相关性，利用它们的独特特征。尽管将基础科学知识转化为临床治疗干预存在相当大的挑战，但本综述为开发针对 AIDN 中非凋亡 PCD 的创新预防和治疗策略提供了理论基础。
