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多片段基因组的管理:霍乱弧菌模型。

Management of multipartite genomes: the Vibrio cholerae model.

机构信息

Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France

出版信息

Curr Opin Microbiol. 2014 Dec;22:120-6. doi: 10.1016/j.mib.2014.10.003.

Abstract

A minority of bacterial species has been found to carry a genome divided among several chromosomes. Among these, all Vibrio species harbor a genome split into two chromosomes of uneven size, with distinctive replication origins whose replication firing involves common and specific factors. Most of our current knowledge on replication and segregation in multi-chromosome bacteria has come from the study of Vibrio cholerae, which is now the model organism for this field. It has been firmly established that replication of the two V. cholerae chromosomes is temporally regulated and coupled to the cell cycle, but the mediators of these processes are as yet mostly unknown. The two chromosomes are also organized along different patterns within the cell and occupy different subcellular domains. The selective advantages provided by this partitioning into two replicons are still unclear and are a key motivation for these studies.

摘要

少数细菌物种被发现其基因组分布在多个染色体上。在这些细菌中,所有弧菌都有一个基因组被分成两个大小不均的染色体,具有独特的复制起点,其复制启动涉及共同和特定的因素。我们目前对多染色体细菌的复制和分离的大部分知识都来自于霍乱弧菌的研究,它现在是这个领域的模式生物。已经明确的是,两个霍乱弧菌染色体的复制是时间上受到调节并与细胞周期偶联的,但是这些过程的介导者目前大多还不清楚。这两个染色体在细胞内也沿着不同的模式组织,并占据不同的亚细胞区域。这种分成两个复制子的分区提供的选择优势尚不清楚,这也是这些研究的一个关键动机。

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