Curr Opin Chem Biol. 2014 Dec;23:71-7. doi: 10.1016/j.cbpa.2014.10.011.
The Tumor Necrosis Factor Receptor-1 (TNFR1) is a central regulator of inflammation, cell death, and cellular proliferation. As such, alterations in TNFR1 signaling are associated with numerous diseases ranging from autoimmune syndromes to cancer. Understanding the regulation of TNFR1 signaling is therefore of considerable importance. The transduction of signaling events in the TNFR1 pathway--from ligand binding through transcriptional regulation--is regulated at nearly every step by post-translational modifications, including ubiquitination. In this review both endogenous and pharmacologic inhibitors of TNFR1 signaling, and how these impact the ubiquitin system, will be discussed.
肿瘤坏死因子受体 1（TNFR1）是炎症、细胞死亡和细胞增殖的中央调节剂。因此，TNFR1 信号转导的改变与许多疾病有关，从自身免疫综合征到癌症。因此，了解 TNFR1 信号转导的调节具有重要意义。TNFR1 途径中的信号转导事件（从配体结合到转录调节）的转导几乎在每个步骤都受到翻译后修饰的调节，包括泛素化。在这篇综述中，将讨论内源性和药理学 TNFR1 信号转导抑制剂，以及它们如何影响泛素系统。
Zotero 插件