Joshi Namrata, Kumar Pankaj, Sharma Shiwakshi, Jayakumar Remya, Mishra Anand, Harsha V, Dash Manoj Kumar
Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
J Ayurveda Integr Med. 2025 Jul 24;16(5):101152. doi: 10.1016/j.jaim.2025.101152.
The paradigm shift with alarmingly high rate of global cancer incidences encourages the application of incinerated gold Nano powder, Swarna Bhasma (SB) due to its exceptional potency, affordability, and minimal toxic effects. Previous experimental investigations were unable to provide a biochemical understanding of the anti-carcinogenic properties of SB.
To evaluate the tumour related markers in blood and possible alteration in hepatic parameters due to SB.
EAC (Ehrlich's Ascites Carcinoma) induced tumour was generated in the female Swiss albino mice divided into 6 groups, namely, Vehicle Control (VC), Disease Control (DC), Standard Control (SC), and Treatment Groups with escalating doses (1.95, 3.9, and 7.8 mg/kg body weight) of SB. Blood serum quantified was measured for the levels of CEA (Carcinoembryonic antigen), TNF-α (Tumour Necrosis Factoralpha), IL-6 (Interleukin-6), ALT (Alanine transaminase), and AST (Aspartate aminotransferase). Changes in daily food consumption, body weight, and tumour volume (with Vernier caliper) were coherently studied and analysed. The data was analysed using One-Way ANOVA and Tukey's Honest Significance Test.
SB demonstrated effective reduction of CEA levels at higher doses, and TNF-α levels at medium doses. Both moderate and high doses exhibited a noteworthy, dosedependent decrease in IL-6 levels. Furthermore, SB led to a dose-dependent reduction in the AST/ALT ratio. A significant reduction in tumour volume were reported in both the moderate and high doses of SB along with marked improvement in anorexia. The higher doses of SB exhibited the serum validated results in the hepatic, renal and the splenic tissues.
The anti-carcinogenic activity of SB appeared to be dose-dependent. The finding also underscored the hepato-protective capability of SB in lower dose by alleviating cancer-related liver damage.
全球癌症发病率惊人地高，这种范式转变促使人们应用焚烧后的金纳米粉——苏尔纳·巴斯马（SB），因为它具有卓越的效力、可承受性和极小的毒性作用。先前的实验研究未能对SB的抗癌特性提供生化方面的理解。
评估血液中与肿瘤相关的标志物以及SB对肝脏参数可能产生的改变。
在雌性瑞士白化小鼠中诱发艾氏腹水癌肿瘤，将其分为6组，即溶剂对照组（VC）、疾病对照组（DC）、标准对照组（SC）以及给予递增剂量（1.95、3.9和7.8毫克/千克体重）SB的治疗组。对血清进行定量检测，以测定癌胚抗原（CEA）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的水平。连贯地研究并分析每日食物摄入量、体重和肿瘤体积（用游标卡尺测量）的变化。使用单因素方差分析和图基诚实显著性检验对数据进行分析。
高剂量的SB能有效降低CEA水平，中剂量的SB能降低TNF-α水平。中高剂量均显示出IL-6水平有显著的剂量依赖性降低。此外，SB导致AST/ALT比值呈剂量依赖性降低。中高剂量的SB均使肿瘤体积显著减小，同时厌食症状明显改善。高剂量的SB在肝脏、肾脏和脾脏组织中呈现出经血清验证的结果。
SB的抗癌活性似乎具有剂量依赖性。该发现还强调了低剂量的SB通过减轻癌症相关的肝损伤而具有的肝脏保护能力。
