建立联系：与宿主膜接触的衣原体 III 型分泌系统的快照。
Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes.
机构信息
Institute of Structural and Molecular Biology, University College London & Birkbeck, Malet Street, London WC1E 7HX, UK.
Crystallography, Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.
出版信息
Curr Opin Microbiol. 2015 Feb;23:1-7. doi: 10.1016/j.mib.2014.09.019. Epub 2014 Oct 24.
Chlamydiae are obligate intracellular bacterial pathogens with an unusual biphasic lifecycle, which is underpinned by two bacterial forms of distinct structure and function. Bacterial entry and replication require a type III secretion system (T3SS), a widely conserved nanomachine responsible for the translocation of virulence effectors into host cells. Recent cell biology experiments supported by electron and cryo-electron tomography have provided fresh insights into Chlamydia-host interactions. In this review, we highlight some of the recent advances, particularly the in situ analysis of T3SSs in contact with host membranes during chlamydial entry and intracellular replication, and the role of the host rough endoplasmic reticulum (rER) at the recently described intracellular 'pathogen synapse'.
衣原体是一种专性细胞内细菌病原体，具有不寻常的两相生命周期，这一生命周期由两种结构和功能截然不同的细菌形式支撑。细菌进入和复制需要一种 III 型分泌系统（T3SS），这是一种广泛保守的纳米机器，负责将毒力效应蛋白易位到宿主细胞中。最近的细胞生物学实验得到电子和冷冻电镜断层扫描的支持，为衣原体-宿主相互作用提供了新的见解。在这篇综述中，我们强调了一些最新进展，特别是在衣原体进入和细胞内复制过程中，原位分析与宿主膜接触的 T3SS ，以及在最近描述的细胞内“病原体突触”中宿主粗面内质网（rER）的作用。
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