衣原体细胞生物学与发病机制。
Chlamydia cell biology and pathogenesis.
作者信息
Elwell Cherilyn, Mirrashidi Kathleen, Engel Joanne
机构信息
Departments of Medicine, Microbiology and Immunology, University of California, San Francisco, California 94143, USA.
出版信息
Nat Rev Microbiol. 2016 Jun;14(6):385-400. doi: 10.1038/nrmicro.2016.30. Epub 2016 Apr 25.
Abstract
Chlamydia spp. are important causes of human disease for which no effective vaccine exists. These obligate intracellular pathogens replicate in a specialized membrane compartment and use a large arsenal of secreted effectors to survive in the hostile intracellular environment of the host. In this Review, we summarize the progress in decoding the interactions between Chlamydia spp. and their hosts that has been made possible by recent technological advances in chlamydial proteomics and genetics. The field is now poised to decipher the molecular mechanisms that underlie the intimate interactions between Chlamydia spp. and their hosts, which will open up many exciting avenues of research for these medically important pathogens.
摘要
衣原体属是人类疾病的重要病因，目前尚无有效的疫苗。这些专性细胞内病原体在一个特殊的膜区室中复制，并利用大量分泌效应蛋白在宿主充满敌意的细胞内环境中存活。在本综述中，我们总结了衣原体蛋白质组学和遗传学的最新技术进展在解读衣原体属与其宿主之间相互作用方面所取得的进展。该领域目前已准备好破译衣原体属与其宿主之间密切相互作用的分子机制，这将为这些具有重要医学意义的病原体开辟许多令人兴奋的研究途径。
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本文引用的文献
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A Coming of Age Story: Chlamydia in the Post-Genetic Era.一个成长的故事：后基因时代的衣原体
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The Chlamydia trachomatis Ctad1 invasin exploits the human integrin β1 receptor for host cell entry.沙眼衣原体 Ctad1 入侵素利用人类整合素 β1 受体进入宿主细胞。
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A working model for the type III secretion mechanism in Chlamydia.衣原体III型分泌机制的工作模型。
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The trans-Golgi SNARE syntaxin 10 is required for optimal development of Chlamydia trachomatis.反式高尔基体SNARE蛋白 syntaxin 10是沙眼衣原体最佳发育所必需的。
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