Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland.
Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland.
Curr Opin Microbiol. 2015 Feb;23:80-5. doi: 10.1016/j.mib.2014.11.007. Epub 2014 Nov 26.
The facultative intracellular bacteria Bartonella spp. share a common infection strategy to invade and colonize mammals in a host-specific manner. Following transmission by blood-sucking arthropods, Bartonella are inoculated in the derma and then spread, via two sequential enigmatic niches, to the blood stream where they cause a long-lasting intra-erythrocytic bacteraemia. The VirB/VirD4 type IV secretion system (VirB/D4 T4SS) is essential for the pathogenicity of most Bartonella species by injecting an arsenal of effector proteins into host cells. These bacterial effector proteins share a modular architecture, comprising domains and/or motifs that confer an array of functions. Here, we review recent advances in understanding the function and evolutionary origin of this fascinating repertoire of host-targeted bacterial effectors.
兼性细胞内细菌巴尔通体属以一种宿主特异性的方式入侵和定殖哺乳动物，共享一种共同的感染策略。通过吸血节肢动物传播后，巴尔通体被接种到真皮中，然后通过两个连续的神秘小生境传播到血液中，在血液中它们引起持久的红细胞内菌血症。VirB/VirD4 型 IV 型分泌系统（VirB/D4 T4SS）通过将一系列效应蛋白注入宿主细胞，对大多数巴尔通体物种的致病性至关重要。这些细菌效应蛋白具有模块化结构，包含赋予一系列功能的结构域和/或基序。在这里，我们综述了理解这组引人入胜的宿主靶向细菌效应蛋白的功能和进化起源的最新进展。
