瘦素基因（LEP）的DNA甲基化与酒精戒断期间的渴望有关。
DNA methylation of the LEP gene is associated with craving during alcohol withdrawal.
作者信息
Hillemacher Thomas, Weinland Christian, Lenz Bernd, Kraus Thomas, Heberlein Annemarie, Glahn Alexander, Muschler Marc A N, Bleich Stefan, Kornhuber Johannes, Frieling Helge
机构信息
Center for Addiction Research (CARe), Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; Molecular Neurosciences Laboratory, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
出版信息
Psychoneuroendocrinology. 2015 Jan;51:371-7. doi: 10.1016/j.psyneuen.2014.10.014. Epub 2014 Oct 23.
Different studies have described evidence for an association between leptin serum levels and craving in alcohol dependent patients. As leptin expression is regulated by DNA methylation we investigated changes of DNA methylation of the LEP gene promoter region in alcohol dependent patients undergoing withdrawal. Results show that low methylation status is associated with increasing serum leptin levels and elevation of craving for alcohol in the referring patients group. These findings point towards a pathophysiological relevance of changes in DNA methylation of the LEP gene promoter region in alcohol dependence.
不同的研究已经描述了酒精依赖患者血清瘦素水平与渴望之间存在关联的证据。由于瘦素表达受DNA甲基化调节，我们研究了正在戒酒的酒精依赖患者中LEP基因启动子区域的DNA甲基化变化。结果显示，在参考患者组中，低甲基化状态与血清瘦素水平升高及对酒精渴望增加相关。这些发现表明LEP基因启动子区域DNA甲基化变化在酒精依赖中具有病理生理学意义。
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