Huang J T, Lajtha A
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):191-9.
The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates. After 7.5 minutes of incubation of 2.5% (w/v) homogenate, 30% of N-terminal tryptophan was released from DSIP, while 75% of N-terminal tyrosine was released from Metenkephalin. The optimal pH of degradation of both peptides was pH 7.35. A rapid increase of breakdown of the peptides was observed during the 10 days of postnatal growth, with breakdown expressed per unit weight of brain. Neither morphine nor deprivation of rapid eye movement (REM) sleep affected the degradation of peptides.
研究了δ-睡眠诱导肽（DSIP）在脑匀浆中的降解情况，并与脑啡肽的降解情况进行了比较。在2.5%（w/v）匀浆孵育7.5分钟后，DSIP释放出30%的N端色氨酸，而脑啡肽释放出75%的N端酪氨酸。两种肽降解的最适pH值均为7.35。在出生后10天的生长过程中，观察到肽的分解迅速增加，分解以每单位脑重量表示。吗啡和快速眼动（REM）睡眠剥夺均不影响肽的降解。
