Thakkar M, Mallick B N
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Sleep. 1993 Dec;16(8):691-4.
Glucose metabolism and energy expenditure are altered during rapid eye movement (REM) sleep. To understand this mechanism, it was hypothesized that the enzymes involved in the metabolism of glucose, viz. hexokinase and glucose-6-phosphatase, are affected by REM sleep deprivation. The flower pot technique was used for 1-, 2- and 4-day periods of REM sleep deprivation. Suitable control experiments were carried out to rule out the nonspecific effects. The results showed that glucose-6-phosphatase was first to be affected, and it showed decreased activity. In longer periods of deprivation, there was an increase in hexokinase activity. Both the altered enzyme activities returned to baseline level on recovery from REM sleep deprivation. Control experiments suggest that alterations were primarily caused by REM sleep deprivation, not nonspecific effects.
快速眼动（REM）睡眠期间葡萄糖代谢和能量消耗会发生改变。为了解这一机制，研究人员提出假说，认为参与葡萄糖代谢的酶，即己糖激酶和葡萄糖-6-磷酸酶，会受到REM睡眠剥夺的影响。采用花盆技术对REM睡眠进行1天、2天和4天的剥夺。进行了适当的对照实验以排除非特异性影响。结果表明，葡萄糖-6-磷酸酶首先受到影响，其活性降低。在更长时间的剥夺中，己糖激酶活性增加。从REM睡眠剥夺恢复后，这两种酶活性的改变均恢复到基线水平。对照实验表明，这些改变主要是由REM睡眠剥夺引起的，而非非特异性影响。
