Jiang Ping, Tokariev Maksym, Aronen Eeva T, Salonen Oili, Ma YuanYe, Vuontela Virve, Carlson Synnöve
Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.
Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland; Brain Research Unit, O.V. Lounasmaa Laboratory and Advanced Magnetic Imaging Centre, Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland.
Brain Cogn. 2014 Dec;92C:61-72. doi: 10.1016/j.bandc.2014.10.005. Epub 2014 Oct 29.
Brain imaging studies have identified two cortical areas, the parahippocampal place area (PPA) and the retrosplenial complex (RSC), that respond preferentially to the viewing of scenes. Contrary to the PPA, little is known about the functional maturation and cognitive control of the RSC. Here we used functional magnetic resonance imaging and tasks that required attention to scene (or face) images and suppression of face (or scene) images, respectively, to investigate task-dependent modulation of activity in the RSC and whole-brain functional connectivity (FC) of this area in 7-11-year-old children and young adults. We compared responsiveness of the RSC with that of the PPA. The RSC was selectively activated by scene images in both groups, albeit less than the PPA. Children modulated activity between the tasks similarly in the RSC and PPA, and to the same extent as adults in PPA, whereas adults modulated activity in the RSC less than in PPA. In children, the whole brain FC of the RSC was stronger in the Sf than Fs task between the left RSC and right fusiform gyrus. The between groups comparison suggested stronger FC in children than adults in the Sf task between the right RSC and the left inferior parietal lobule and intraparietal sulcus. Together the results suggest that the function of the RSC and the related networks undergo dynamic changes over the development from 7-11-year-old children to adulthood.
脑成像研究已经确定了两个皮质区域，即海马旁位置区（PPA）和压后复合体（RSC），它们对场景的观看有优先反应。与PPA不同，人们对RSC的功能成熟和认知控制知之甚少。在这里，我们使用功能磁共振成像以及分别需要关注场景（或面部）图像和抑制面部（或场景）图像的任务，来研究7至11岁儿童和年轻人中RSC活动的任务依赖性调节以及该区域的全脑功能连接（FC）。我们比较了RSC和PPA的反应性。两组中RSC均被场景图像选择性激活，尽管程度低于PPA。儿童在RSC和PPA中对任务间活动的调节方式相似，且在PPA中与成年人的调节程度相同，而成年人对RSC活动的调节程度低于PPA。在儿童中，在左RSC和右梭状回之间，RSC的全脑功能连接在关注场景而非面部任务（Sf）中更强。组间比较表明，在右RSC与左顶下小叶和顶内沟之间的关注场景而非面部任务（Sf）中，儿童的功能连接比成年人更强。这些结果共同表明，从7至11岁儿童到成年期的发育过程中，RSC及其相关网络的功能会发生动态变化。
