Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and.
J Neurosci. 2019 Jan 23;39(4):705-717. doi: 10.1523/JNEUROSCI.1219-18.2018. Epub 2018 Nov 30.
Human retrosplenial complex (RSC), located in medial parietal cortex, has been implicated in numerous cognitive functions, including scene perception, spatial navigation, and autobiographical memory retrieval. Recently, a posterior-anterior distinction within RSC was proposed, such that posterior aspects process scene-related visual information (constituting a medial place area [MPA]), whereas anterior aspects process information that is vividly retrieved from memory, thereby supporting remembering and potentially navigation. Here, we tested this proposed distinction in a single group of participants (both male and female) using fMRI with both perceptual and mnemonic tasks. After completing a resting-state scan, participants performed a task that required constructing scenes from memory and completed a scene selectivity localizer task. We tested directly perceptual and mnemonic responses in MPA and an anterior, connectivity-defined region (CON), which showed strong functional connectivity with anterior parahippocampal place area. A double dissociation was observed, such that CON was more strongly activated during scene construction than was MPA, whereas MPA was more perceptually responsive than CON. Further, peak responses from the scene construction task were anterior to perceptual peaks in all but 1 participant and hemisphere. Finally, through analyses of the posterior-anterior response profiles, we identify the fundus of the parieto-occipital sulcus as a potential location for the crossover from perceptual to mnemonic representations and highlight a potential left-hemisphere advantage for mnemonic representations. Collectively, our results support a distinction between posterior and anterior aspects of the RSC, suggesting that more specific functional-anatomic terms should be used in its place in future work. The retrosplenial complex (RSC) has been implicated in vision, spatial cognition, and memory. We previously speculated on a potential posterior-anterior distinction within RSC for scene perception and memory-based scene construction/navigation. Here, we tested this distinction through a combination of resting-state, perceptual, and mnemonic task data. Consistent with our predictions, we demonstrate that perceptual responses peak consistently posterior of those elicited by memory-based scene construction within the broader RSC. Further, we highlight (1) the fundus of the parieto-occipital sulcus as a landmark for the transition between these representations, (2) the anterior bank of parieto-occipital sulcus as the point of maximal separation between these representations, and (3) identify a potential hemispheric asymmetry in mnemonic representations. These data support functional dissociations within RSC.
人类后扣带回复合体（RSC）位于内侧顶叶皮层，与多种认知功能有关，包括场景感知、空间导航和自传体记忆检索。最近，人们提出了 RSC 内的前后区分，即后部处理与场景相关的视觉信息（构成内侧位置区域[MPA]），而前部处理从记忆中生动检索到的信息，从而支持记忆和潜在的导航。在这里，我们使用 fMRI 结合知觉和记忆任务，在一组参与者（男性和女性）中测试了这种提议的区分。在完成静息状态扫描后，参与者完成了一项从记忆中构建场景的任务，并完成了场景选择性定位任务。我们直接测试了 MPA 和一个与前内侧旁海马位置区具有强烈功能连接的连接定义区域（CON）的知觉和记忆反应。观察到双分离，即 CON 在场景构建中比 MPA 更强烈地激活，而 MPA 在知觉上比 CON 更敏感。此外，在除了 1 名参与者和 1 个半球之外的所有参与者中，场景构建任务的峰值反应都在前部。最后，通过对前后反应轮廓的分析，我们确定顶枕沟底作为从知觉到记忆表征的转换的潜在位置，并突出了记忆表征的潜在左半球优势。总的来说，我们的结果支持 RSC 后部和前部之间的区分，表明在未来的工作中应该使用更具体的功能-解剖术语来取代它。后扣带回复合体（RSC）与视觉、空间认知和记忆有关。我们之前推测 RSC 内可能存在用于场景感知和基于记忆的场景构建/导航的前后区分。在这里，我们通过静息状态、知觉和记忆任务数据的组合来测试这种区分。与我们的预测一致，我们证明在更广泛的 RSC 内，基于记忆的场景构建引起的记忆反应峰值始终位于知觉反应之后。此外，我们强调了（1）顶枕沟底部作为这些表示之间转换的地标，（2）顶枕沟前嵴作为这些表示之间最大分离的点，以及（3）识别记忆表示中潜在的半球不对称性。这些数据支持 RSC 内的功能分离。
