Song Taejong, Lee Yoo-Young, Choi Chel Hun, Kim Tae-Joong, Lee Jeong-Won, Bae Duk-Soo, Kim Byoung-Gie
Department of Obstetrics & Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Obstetrics & Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Gangnam-gu, Seoul 135-710, Republic of Korea.
Eur J Obstet Gynecol Reprod Biol. 2015 Jan;184:38-42. doi: 10.1016/j.ejogrb.2014.10.001. Epub 2014 Oct 14.
Borderline ovarian tumor (BOT) is uncommon in women with advanced age. The authors investigated the characteristics and treatment outcomes of women with BOT ≥ 65 years of age.
A hospital-based tumor registry was used to identify retrospectively patients with BOT who were treated between 1996 and 2011. Patients were divided into two cohorts: women aged <65 years and women aged ≥ 65 years. Recurrence and survival was examined using the Kaplan-Meier method. Multivariate Cox proportional hazards model was used to estimate hazard ratios with 95% confidence intervals (95% CI).
In total, 364 patients were identified, including 326 patients aged <65 years and 38 patients aged ≥ 65 years. The elderly patients had more comorbidities (P < 0.001), larger tumor size at diagnosis (P = 0.001), more perioperative complications (P = 0.001), and longer postoperative hospital stay (P < 0.001). In a multivariate model, the hazard ratios for recurrence and disease-related death in patients aged ≥ 65 years were 2.53 (95% CI, 1.03-6.23) and 7.66 (95% CI, 1.09-53.95), respectively.
Characteristics and survival of patients with BOTs aged ≥ 65 years differ distinctly from those of patients aged <65 years. Old age was an independent poor prognostic factor of recurrence and disease-related death.
交界性卵巢肿瘤（BOT）在老年女性中并不常见。作者调查了年龄≥65岁的BOT女性患者的特征及治疗结果。
利用基于医院的肿瘤登记系统对1996年至2011年间接受治疗的BOT患者进行回顾性识别。患者被分为两个队列：年龄<65岁的女性和年龄≥65岁的女性。采用Kaplan-Meier法检查复发和生存情况。使用多变量Cox比例风险模型估计风险比及95%置信区间（95%CI）。
共识别出364例患者，其中年龄<65岁的患者326例，年龄≥65岁的患者38例。老年患者合并症更多（P<0.001），诊断时肿瘤更大（P = 0.001），围手术期并发症更多（P = 0.001），术后住院时间更长（P<0.001）。在多变量模型中，年龄≥65岁患者复发和疾病相关死亡的风险比分别为2.53（95%CI，1.03 - 6.23）和7.66（95%CI，1.09 - 53.95）。
年龄≥65岁的BOT患者的特征和生存情况与年龄<65岁的患者明显不同。高龄是复发和疾病相关死亡的独立不良预后因素。
