Yoshioka S, Iribe K, Miyayama H, Ushio Y
Department of Neurosurgery, Kumamoto Municipal Hospital, Japan.
No To Shinkei. 1992 Dec;44(12):1137-41.
A 3-year-old boy presented with multiple brain metastases 21 months after the resection of stage II Wilms' tumor. Metastasis to other organs was not found. He was treated by total removal of a large metastatic tumor in the left temporal lobe and post-operative radiotherapy and chemotherapy. He has been in complete remission for 20 months after surgery. Cerebral metastasis from Wilms' tumor without systemic metastases is very rare. It is speculated that brain metastases occurred in this patient because most of the anticancer agents used in the primary treatment for Wilms' tumor were not able to cross the blood brain barrier.
一名3岁男孩在II期威尔姆斯瘤切除术后21个月出现多处脑转移。未发现其他器官转移。他接受了左颞叶一个大转移瘤的全切手术以及术后放疗和化疗。术后他已完全缓解20个月。威尔姆斯瘤发生脑转移而无全身转移非常罕见。据推测,该患者发生脑转移是因为威尔姆斯瘤初始治疗中使用的大多数抗癌药物无法穿过血脑屏障。