Kirenskaia A V, Storozheva Z I, Miamlin V V, Tkachenko A A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2013 Nov-Dec;63(6):625-42. doi: 10.7868/s0044467713060087.
The endophenotype concept is considered as theoretical basis for the study of pathobiological mechanisms of schizophrenia and for the development of the complex of instrumental diagnostic methods. The contemporary state of the problem and the most significant results of the study of three neurophysiological schizophrenia endophenotypes are presented in the review: P50 auditory evoked potential suppression, prepulse inhibition of the startle reflex and antisaccade task. The current understanding of the underlying neurophysiological and neurochemical mechanisms is described for each measure. The results of the association studies of neurophysiological endophenotypes with the relevant to schizophrenia genes' polymorphisms are laid down. High degree of independence of the considered endophenotypes is demonstrated. Taking into account the data on relatively low specificity of each endophenotype to schizophrenia compared to other mental disturbances the authors pay special attention to the model of multivariate endophenotype as a scientific and diagnostic tool.
内表型概念被视为研究精神分裂症病理生物学机制以及开发综合仪器诊断方法的理论基础。本文综述了该问题的当代研究现状以及三种神经生理精神分裂症内表型研究的最重要成果：P50听觉诱发电位抑制、惊跳反射的前脉冲抑制和反扫视任务。针对每种测量方法描述了对潜在神经生理和神经化学机制的当前理解。阐述了神经生理内表型与精神分裂症相关基因多态性的关联研究结果。结果表明所考虑的内表型具有高度独立性。鉴于与其他精神障碍相比，每种内表型对精神分裂症的特异性相对较低，作者特别关注多变量内表型模型作为一种科学和诊断工具。
