Wu Shiwu, Yu Lan, Zhou Lei, Cheng Zenong, Wang Danna
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):865-9.
The present paper aims to investigate whether or not vasculogenic mimicry (VM) exists in laryngeal squamous cell carcinoma (LSCC), and to elucidate its relationship to microvessel density (MVD), galectin-3 (Gal-3) expression, and clinicopathological factors of patients with LSCC. VM, score of MVD and expression of Gal-3 protein were detected by immunohistochemistry and histochemistry in 83 specimens of LSCC tissue and 20 specimens of normal laryngeal tissue. The positive rate of VM in normal laryngeal tissues was 0%, and was 33.7% in LSCC tissues. There was a significant difference between the two groups (P<0. 01). VM or MVD was significantly related to differentiation, pTNM stages and lymph node metastasis of LSCC (P<0.05), but not to age, gender and tumor site (P>0. 05). And there was a positive correlation between every two of VM, score of MVD, and Gal-3 protein (P< 0. 05). The results suggest that expression of Gal-3 protein may be related to the initiation, angiogenesis and VM formation in LSCC; And VM, angiogenesis and Gal-3 protein may be involved in the development, invasion and metastasis of LSCC.
本文旨在研究喉鳞状细胞癌（LSCC）中是否存在血管生成拟态（VM），并阐明其与微血管密度（MVD）、半乳糖凝集素-3（Gal-3）表达以及LSCC患者临床病理因素之间的关系。采用免疫组织化学和组织化学方法检测83例LSCC组织标本和20例正常喉组织标本中的VM、MVD评分及Gal-3蛋白表达。正常喉组织中VM阳性率为0%，LSCC组织中为33.7%。两组间差异有统计学意义（P<0.01）。VM或MVD与LSCC的分化、pTNM分期及淋巴结转移显著相关（P<0.05），但与年龄、性别及肿瘤部位无关（P>0.05）。VM、MVD评分及Gal-3蛋白两两之间呈正相关（P<0.05）。结果提示，Gal-3蛋白表达可能与LSCC的发生、血管生成及VM形成有关；VM、血管生成及Gal-3蛋白可能参与LSCC的发展、侵袭和转移。
