具有高机械强度和细胞粘附特性的纳米羟基磷灰石/聚丙烯酰胺复合水凝胶。
Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties.
作者信息
Li Zhiyong, Mi Wenying, Wang Huiliang, Su Yunlan, He Changcheng
机构信息
College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
College of Chemistry, Beijing Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, PR China.
出版信息
Colloids Surf B Biointerfaces. 2014 Nov 1;123:959-64. doi: 10.1016/j.colsurfb.2014.10.050.
Nano-hydroxyapatite/polyacrylamide composite hydrogels were successfully fabricated by physically mixing nano-hydroxyapatite (nHAp) particles into a peroxidized micelles initiated and cross-linked (pMIC) polyacrylamide (PAAm) hydrogel. The nanocomposite hydrogels exhibited excellent mechanical properties. The fracture tensile stresses of the gels were in the range of 0.21-0.86 MPa and the fracture tensile strains were up to 30 mm/mm, and the compressive strengths were up to 35.8 MPa. Meanwhile the introduction of nHAp endowed the composite hydrogels with good cell adhesion properties. This nHAp/PAAm nanocomposite hydrogel is expected to find potential applications in tissue engineering.
通过将纳米羟基磷灰石（nHAp）颗粒物理混合到过氧化物引发和交联（pMIC）的聚丙烯酰胺（PAAm）水凝胶中，成功制备了纳米羟基磷灰石/聚丙烯酰胺复合水凝胶。该纳米复合水凝胶表现出优异的力学性能。凝胶的断裂拉伸应力在0.21 - 0.86 MPa范围内，断裂拉伸应变高达30 mm/mm，抗压强度高达35.8 MPa。同时，nHAp的引入赋予了复合水凝胶良好的细胞粘附性能。这种nHAp/PAAm纳米复合水凝胶有望在组织工程中找到潜在应用。
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