Aprahamian Ivan, Radanovic Marcia, Nunes Paula Villela, Ladeira Rodolfo Braga, Forlenza Orestes Vicente
Laborarório de Neurociência LIM 27, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2014 Dec;72(12):913-8. doi: 10.1590/0004-282X20140153. Epub 2014 Dec 2.
There is limited data regarding the cognitive profile from screening tests of older adults with bipolar disorder (BD) with dementia. Objective To investigate the Clock Drawing Test (CDT) among older adults with BD with and without Alzheimer's disease (AD). Method 209 older adults (79 with BD without dementia and 70 controls; 60 with AD, being 27 with BD) were included to evaluate the performance of three CDT scoring scales, beyond the Mini-Mental State Examination (MMSE) and verbal fluency (VFT). Results Patients with BD without dementia presented with lower scores in MMSE, VF and one CDT scoring scale than controls. Patients with BD and AD presented with lower scores in VF and CDT scoring scales than patients with only AD. All CDT scales presented similar sensitivity and specificity for BD and non-BD groups. Conclusion Elderly subjects with BD showed greater impairment in CDT in both groups of normal cognition and AD.
关于患有双相情感障碍（BD）且伴有痴呆症的老年人筛查测试的认知概况的数据有限。目的：研究患有和未患有阿尔茨海默病（AD）的双相情感障碍老年患者的画钟试验（CDT）。方法：纳入209名老年人（79名无痴呆症的双相情感障碍患者和70名对照；60名患有AD，其中27名患有双相情感障碍），以评估除简易精神状态检查表（MMSE）和语言流畅性测试（VFT）之外的三种CDT评分量表的表现。结果：无痴呆症的双相情感障碍患者在MMSE、VF和一种CDT评分量表中的得分低于对照组。患有双相情感障碍和AD的患者在VF和CDT评分量表中的得分低于仅患有AD的患者。所有CDT量表对双相情感障碍组和非双相情感障碍组的敏感性和特异性相似。结论：在正常认知和AD两组中，患有双相情感障碍的老年受试者在CDT中表现出更大的损伤。
