Department of Obstetrics and Gynaecology, Inselspital, Berne University Hospital, Effingerstrasse 102, Berne CH-3010, Switzerland; Department of Clinical Research, University of Berne, Murtenstrasse 35, Berne CH-3010, Switzerland.
Department of Obstetrics and Gynaecology, Inselspital, Berne University Hospital, Effingerstrasse 102, Berne CH-3010, Switzerland.
Trends Endocrinol Metab. 2015 Jan;26(1):1-10. doi: 10.1016/j.tem.2014.10.003. Epub 2014 Nov 19.
Endometriosis is an extremely prevalent estrogen-dependent condition characterized by the growth of ectopic endometrial tissue outside the uterine cavity, and is often presented with severe pain. Although the relationship between lesion and pain remains unclear, nerve fibers found in close proximity to endometriotic lesions may be related to pain. Also, women with endometriosis pain develop central sensitization. Endometriosis creates an inflammatory environment and recent research is beginning to elucidate the role of inflammation in stimulating peripheral nerve sensitization. In this review, we discuss endometriosis-associated inflammation, peripheral nerve fibers, and assess their potential mechanism of interaction. We propose that an interaction between lesions and nerve fibers, mediated by inflammation, may be important in endometriosis-associated pain.
子宫内膜异位症是一种极其常见的雌激素依赖性疾病，其特征是子宫内膜组织在子宫腔外生长，常伴有严重疼痛。虽然病变与疼痛之间的关系尚不清楚，但在子宫内膜异位症病灶附近发现的神经纤维可能与疼痛有关。此外，患有子宫内膜异位症疼痛的女性会出现中枢敏化。子宫内膜异位症会产生炎症环境，最近的研究开始阐明炎症在刺激周围神经敏化中的作用。在这篇综述中，我们讨论了与子宫内膜异位症相关的炎症、外周神经纤维，并评估了它们潜在的相互作用机制。我们提出，病变和神经纤维之间的相互作用，可能是由炎症介导的，这在与子宫内膜异位症相关的疼痛中可能很重要。
