Zhou Liyuan, Liu Boya, Jian Xian, Jiang Lili, Liu Kuiran
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Nutr. 2025 Mar 12;12:1539665. doi: 10.3389/fnut.2025.1539665. eCollection 2025.
Endometriosis is an estrogen-dependent chronic inflammatory disease which causes dysmenorrhea, chronic pelvic pain, and infertility in women of childbearing age, significantly impacting their quality of life and physical and mental health. The etiology of endometriosis remains unclear, with oxidative stress and inflammation currently thought to play pivotal roles in its pathophysiology. Epidemiological studies and clinical trials indicate that varying dietary patterns and specific nutrient supplementation can influence oxidative stress markers and levels of inflammatory factors and related pathways, potentially impacting the progression of endometriosis. In this review, we summarize the roles of oxidative stress and inflammation in endometriosis and thoroughly examine the current understanding of the effect of dietary patterns and nutrient supplementation in treating endometriosis. This study suggests that nutrients may prevent the occurrence of endometriosis by modulating levels of inflammatory factors, regulating angiogenesis, and influencing the metabolism of estrogen pathways. The findings might provide new insights into the treatment of endometriosis patients and the potential benefits of dietary patterns and nutrient supplementation in patients with endometriosis.
子宫内膜异位症是一种雌激素依赖性慢性炎症性疾病，可导致育龄期女性痛经、慢性盆腔疼痛和不孕，严重影响其生活质量以及身心健康。子宫内膜异位症的病因尚不清楚，目前认为氧化应激和炎症在其病理生理学中起关键作用。流行病学研究和临床试验表明，不同的饮食模式和特定的营养补充剂可影响氧化应激标志物、炎症因子水平及相关途径，可能影响子宫内膜异位症的进展。在本综述中，我们总结了氧化应激和炎症在子宫内膜异位症中的作用，并深入探讨了目前对饮食模式和营养补充剂在治疗子宫内膜异位症方面作用的认识。本研究表明，营养素可能通过调节炎症因子水平、调节血管生成以及影响雌激素途径的代谢来预防子宫内膜异位症的发生。这些发现可能为子宫内膜异位症患者的治疗以及饮食模式和营养补充剂对子宫内膜异位症患者的潜在益处提供新的见解。
