头颈部癌症中 (18)F-BPA 和 (18)F-FDG 摄取的相关性。
Correlation of (18)F-BPA and (18)F-FDG uptake in head and neck cancers.
机构信息
Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan; Department of Radiology, Nippon Medical School, Tokyo, Japan.
Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
出版信息
Radiother Oncol. 2014 Nov;113(2):193-7. doi: 10.1016/j.radonc.2014.11.001. Epub 2014 Nov 18.
BACKGROUND AND PURPOSE
The aim of this study was to compare the accumulation of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) with that of (18)F-fluorodeoxyglucose ((18)F-FDG) in head and neck cancers, and to assess the usefulness of (18)F-FDG PET for screening candidates for boron neutron capture therapy (BNCT).
MATERIAL AND METHODS
Twenty patients with pathologically proven malignant tumors of the head and neck were recruited from March 2012 to January 2014. All patients underwent both whole-body (18)F-BPA PET/CT and (18)F-FDG PET/CT within 2weeks of each other. The uptakes of (18)F-BPA and (18)F-FDG at 1h after injection were evaluated using the maximum standardized uptake value (SUVmax).
RESULTS
The accumulation of (18)F-FDG was significantly correlated with that of (18)F-BPA. The SUVmax of (18)F-FDG ⩾5.0 is considered to be suggestive of high (18)F-BPA accumulation.
CONCLUSIONS
(18)F-FDG PET might be an effective screening method performed prior to (18)F-BPA for selecting patients with head and neck cancer for treatment with BNCT.
背景与目的
本研究旨在比较 4-硼-2-[18F]氟代苯丙氨酸（[18F]BPA）与[18F]氟代脱氧葡萄糖（[18F]FDG）在头颈部癌症中的积累，并评估[18F]FDG PET 对头颈部癌症硼中子俘获治疗（BNCT）候选者进行筛选的有用性。
材料与方法
2012 年 3 月至 2014 年 1 月期间，招募了 20 名经病理证实的头颈部恶性肿瘤患者。所有患者均在 2 周内分别接受全身[18F]BPA PET/CT 和[18F]FDG PET/CT 检查。在注射后 1 小时，使用最大标准化摄取值（SUVmax）评估[18F]BPA 和[18F]FDG 的摄取。
结果
[18F]FDG 的积累与[18F]BPA 的积累显著相关。SUVmax of [18F]FDG ⩾5.0 被认为提示[18F]BPA 积累较高。
结论
[18F]FDG PET 可能是一种有效的筛选方法，可在[18F]BPA 之前进行，用于选择头颈部癌症患者接受 BNCT 治疗。
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