来自越南槐根茎和根的具有白细胞介素-6产生抑制活性的黄酮类化合物和芳基苯并呋喃类化合物。
Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity.
作者信息
Yoo Hunseung, Chae Hee-Sung, Kim Young-Mi, Kang Minseok, Ryu Keun Ho, Ahn Hee Chul, Yoon Kee Dong, Chin Young-Won, Kim Jinwoong
机构信息
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea; New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea.
College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2014 Dec 15;24(24):5644-5647. doi: 10.1016/j.bmcl.2014.10.077. Epub 2014 Oct 30.
Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.
从越南槐的根茎中分离出三种新化合物（1-3）和20种已知化合物，并对所有分离物进行了测试，考察其对佛波酯（PMA）加离子载体A23187刺激的HMC-1细胞中白细胞介素-6（IL-6）产生的抑制活性。在测试的化合物中，发现化合物1、5、9和21能够有效抑制IL-6的产生，其半数抑制浓度（IC50）值分别为1.62、0.73、3.01和4.02 μM。
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