戴维酮 F 和 G，来自 （Franch.）Skeels 的两种新型类黄酮。
Davidones F and G, Two Novel Flavonoids from (Franch.) Skeels.
机构信息
School of Chemistry and Chemical Engineering, Qinghai Nationalities University, Xining 810007, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
出版信息
Molecules. 2021 Jul 9;26(14):4182. doi: 10.3390/molecules26144182.
An unprecedented novel flavanone davidone F () with a seven-membered ring side chain, and a novel flavanonol davidone G (), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of and were determined by calculation of NMR chemical shift values, the absolute configuration of and were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds - were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds and showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL.
从（Franch.）Skeels 的乙酸乙酯部分分离得到了一种前所未有的七元环侧链黄酮酮 F（）和一种新型的黄酮醇酮 G（），以及 11 种已知的类黄酮。通过 UV、IR、HRESIMS、1D 和 2D NMR 数据确定了它们的平面结构。通过计算 NMR 化学位移值确定了和的相对构型，通过比较实验和计算的电子圆二色谱（ECD）光谱确定了和的绝对构型。此外，对葡萄糖转运蛋白 4（GLUT-4）的转运活性进行了筛选，荧光强度增加到 1.56 倍和 2.79 倍。化合物 - 在 20 μg/mL 浓度下，分别以 1.64 倍和 1.79 倍的增强作用显示出中等的 GLUT-4 转运活性。
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