Hartman P E, Goldstein M A
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218.
Environ Mol Mutagen. 1989;14(1):42-7. doi: 10.1002/em.2850140108.
Anthraquinones (AQs) comprise one important class of secondary metabolites predominantly produced by fungi and higher plants but also produced by a variety of other organisms. Humans orally ingest AQs from environmental sources as well as through direct use as nonprescription laxatives, and some AQ derivatives are used as topically applied antipsoritic agents. Some AQs are mutagenic. We present evidence that aqueous solutions of several AQs in the presence of an appropriate reducing agent and dissolved oxygen generate superoxide when they are illuminated with broad-spectrum light. Redox cycling of AQs could be responsible for some aspects of their toxicity in biological systems.
蒽醌（AQs）是一类重要的次生代谢产物，主要由真菌和高等植物产生，但也可由多种其他生物体产生。人类通过环境来源口服摄入蒽醌，也会直接将其用作非处方泻药，一些蒽醌衍生物还被用作局部应用的抗银屑病药物。某些蒽醌具有致突变性。我们提供的证据表明，几种蒽醌的水溶液在存在适当还原剂和溶解氧的情况下，受到广谱光照时会产生超氧化物。蒽醌的氧化还原循环可能是其在生物系统中产生某些毒性的原因。
