State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Molecules. 2022 Jun 14;27(12):3831. doi: 10.3390/molecules27123831.
The anthraquinones (AQs) and derivatives are widely distributed in nature, including plants, fungi, and insects, with effects of anti-inflammation and anti-oxidation, antibacterial and antiviral, anti-osteoporosis, anti-tumor, etc. Inflammation, including acute and chronic, is a comprehensive response to foreign pathogens under a variety of physiological and pathological processes. AQs could attenuate symptoms and tissue damages through anti-inflammatory or immuno-modulatory effects. The review aims to provide a scientific summary of AQs on immune responses under different pathological conditions, such as digestive diseases, respiratory diseases, central nervous system diseases, etc. It is hoped that the present paper will provide ideas for future studies of the immuno-regulatory effect of AQs and the therapeutic potential for drug development and clinical use of AQs and derivatives.
蒽醌类（AQs）及其衍生物广泛存在于自然界中，包括植物、真菌和昆虫，具有抗炎、抗氧化、抗菌、抗病毒、抗骨质疏松、抗肿瘤等作用。炎症包括急性和慢性炎症，是在多种生理和病理过程中对外来病原体的综合反应。AQs 可以通过抗炎或免疫调节作用来减轻症状和组织损伤。本综述旨在对不同病理条件下（如消化系统疾病、呼吸系统疾病、中枢神经系统疾病等） AQs 对免疫反应的作用进行科学总结。希望本文能为 AQs 的免疫调节作用及其作为药物开发和临床应用的治疗潜力的研究提供思路。
