State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, PR China.
Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, PR China.
Biomaterials. 2015 Jan;39:206-17. doi: 10.1016/j.biomaterials.2014.11.009. Epub 2014 Nov 22.
Two-dimensional transition metal dichalcogenides, particularly MoS2 nanosheets, have been deemed as a novel category of NIR photothermal transducing agent. Herein, an efficient and versatile one-pot solvothermal synthesis based on "bottom-up" strategy has been, for the first time, proposed for the controlled synthesis of PEGylated MoS2 nanosheets by using a novel "integrated" precursor containing both Mo and S elements. This facile but unique PEG-mediated solvothermal procedure endowed MoS2 nanosheets with controlled size, increased crystallinity and excellent colloidal stability. The photothermal performance of nanosheets was optimized via modulating the particulate size and surface PEGylation. PEGylated MoS2 nanosheets with desired photothermal conversion performance and excellent colloidal and photothermal stability were further utilized for highly efficient photothermal therapy of cancer in a tumor-bearing mouse xenograft. Without showing observable in vitro and in vivo hemolysis, coagulation and toxicity, the optimized MoS2-PEG nanosheets showed promising in vitro and in vivo anti-cancer efficacy.
二维过渡金属二硫属化物，特别是 MoS2 纳米片，被认为是一类新型的近红外光热转换剂。在此，首次提出了一种基于“自下而上”策略的高效、通用的一锅溶剂热合成方法，通过使用新型的含有 Mo 和 S 元素的“集成”前体制备 PEG 化 MoS2 纳米片。这种简单但独特的 PEG 介导的溶剂热过程赋予了 MoS2 纳米片可控的尺寸、提高的结晶度和优异的胶体稳定性。通过调节颗粒尺寸和表面 PEG 化，优化了纳米片的光热性能。具有所需光热转换性能和优异胶体和光热稳定性的 PEG 化 MoS2 纳米片进一步用于荷瘤小鼠异种移植模型中的高效光热治疗癌症。优化后的 MoS2-PEG 纳米片在体外和体内均未表现出可观察到的溶血、凝血和毒性，显示出有前景的体外和体内抗癌疗效。
